Rudolph L Leibel Selected Research

Agouti Signaling Protein

5/2011	Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein.
9/2006	The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity.
11/2002	The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.

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Rudolph L Leibel Research Topics

Disease

32	Obesity 10/2023 - 11/2002
23	Body Weight (Weight, Body) 01/2020 - 05/2002
18	Weight Loss (Weight Reduction) 01/2021 - 05/2002
8	Insulin Resistance 01/2021 - 01/2006
8	Weight Gain 01/2021 - 02/2003
4	Hyperglycemia 10/2023 - 01/2005
4	Retinitis Pigmentosa (Pigmentary Retinopathy) 02/2019 - 01/2011
4	Inflammation (Inflammations) 01/2019 - 01/2006
3	Hyperinsulinism (Hyperinsulinemia) 10/2023 - 05/2014
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 12/2022 - 01/2018
3	Prader-Willi Syndrome (Syndrome, Prader-Willi) 01/2021 - 01/2017
3	Atherosclerosis 11/2019 - 01/2005
3	Hyperphagia (Overeating) 02/2019 - 10/2014
3	Overweight 10/2018 - 09/2015
2	Dyslipidemias (Dyslipidemia) 01/2018 - 01/2018
2	Morbid Obesity 02/2016 - 03/2014
2	Schizophrenia (Dementia Praecox) 11/2014 - 01/2011
1	Diabetes Mellitus 01/2022
1	Bardet-Biedl Syndrome (Syndrome, Bardet-Biedl) 01/2021
1	Melanoma (Melanoma, Malignant) 01/2020
1	Hypoglycemia (Reactive Hypoglycemia) 01/2019
1	Chromosomal Instability (Chromosome Stability) 01/2018
1	Glucose Intolerance 01/2018
1	Lipodystrophy 01/2018
1	Hypogonadism (Hypergonadotropic Hypogonadism) 01/2017
1	Abdominal Obesity 01/2017
1	Hypersensitivity (Allergy) 01/2017
1	Wolfram Syndrome (Syndrome, Wolfram) 03/2014
1	Type 2 Maturity-Onset Diabetes of the Young 01/2013
1	Sepsis (Septicemia) 12/2012
1	Multiple Endocrine Neoplasia Type 2a (MEN 2) 09/2011
1	Infections 03/2011
1	Amebiasis (Amoebiasis) 03/2011

Drug/Important Bio-Agent (IBA)

29	LeptinIBA 12/2020 - 05/2002
14	Insulin (Novolin)FDA Link 12/2022 - 02/2003
13	Glucose (Dextrose)FDA LinkGeneric 10/2023 - 01/2006
9	antineoplaston A10 (A 10)IBA 11/2018 - 05/2002
7	Hormones (Hormone)IBA 10/2019 - 12/2003
6	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2008
5	Leptin ReceptorsIBA 01/2017 - 01/2011
4	GTP Phosphohydrolases (GTPases)IBA 02/2019 - 01/2011
4	Protein Isoforms (Isoforms)IBA 11/2018 - 01/2011
3	Triglycerides (Triacylglycerol)IBA 01/2020 - 01/2005
3	CarbohydratesIBA 01/2019 - 08/2016
3	Thyroid HormonesIBA 11/2018 - 05/2002
3	Antipsychotic Agents (Antipsychotics)IBA 01/2018 - 01/2011
3	Messenger RNA (mRNA)IBA 11/2011 - 07/2004
3	Agouti Signaling ProteinIBA 05/2011 - 11/2002
2	Growth Hormone (Somatotropin)IBA 01/2021 - 01/2017
2	AdipokinesIBA 01/2020 - 03/2014
2	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 02/2019 - 09/2015
2	DioxygenasesIBA 02/2019 - 01/2018
2	LipidsIBA 01/2019 - 01/2018
2	Triiodothyronine (Liothyronine)FDA LinkGeneric 11/2018 - 12/2005
2	HDL CholesterolIBA 03/2014 - 01/2005
2	AdiponectinIBA 03/2014 - 01/2006
2	Dihydrotachysterol (AT 10)IBA 02/2012 - 05/2002
2	EnzymesIBA 11/2011 - 01/2010
2	MelanocortinsIBA 09/2006 - 02/2006
1	A-Form DNA (A-DNA)IBA 10/2023
1	RNA (Ribonucleic Acid)IBA 01/2021
1	MonoglyceridesIBA 01/2020
1	Dietary Fats (Dietary Fat)IBA 01/2020
1	AntigensIBA 01/2020
1	NeuropeptidesIBA 01/2020
1	Cellular Retinol-Binding ProteinsIBA 01/2020
1	Aligeron (AS 2)IBA 11/2019
1	Neuropeptide YIBA 02/2019
1	Levodopa (L Dopa)FDA LinkGeneric 01/2019
1	IncretinsIBA 01/2019
1	Tyrosine (L-Tyrosine)FDA Link 01/2019
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 11/2018
1	iloperidone FDA Link 01/2018
1	Olanzapine (Zyprexa)FDA Link 01/2018
1	Dimethyl Sulfoxide (DMSO)FDA LinkGeneric 01/2018
1	Proprotein Convertase 1IBA 01/2017
1	ElementsIBA 01/2016
1	Transcription Factors (Transcription Factor)IBA 01/2016
1	Agouti-Related ProteinIBA 09/2015
1	Branched-Chain Amino AcidsIBA 05/2014
1	Interleukin-6 (Interleukin 6)IBA 03/2014
1	GlucokinaseIBA 01/2013
1	CytokinesIBA 12/2012
1	Adenosine Triphosphatases (ATPase)IBA 11/2011
1	MineralsIBA 09/2011
1	Glutamine (L-Glutamine)FDA Link 03/2011
1	Insulin ReceptorIBA 03/2011
1	Cytokine Receptors (Cytokine Receptor)IBA 03/2011

Therapy/Procedure

4	Injections 02/2012 - 05/2002
3	Therapeutics 01/2021 - 11/2018
2	Drug Therapy (Chemotherapy) 01/2021 - 10/2014
2	Ketogenic Diet 01/2019 - 08/2016
2	Caloric Restriction 10/2014 - 05/2014
1	Resistance Training 10/2018
1	Duration of Therapy 01/2018
1	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2018
1	Bariatric Surgery 10/2014
1	Diet Therapy (Therapy, Diet) 10/2014
1	Gastric Bypass (Roux-en-Y Gastric Bypass) 10/2014
1	Biliopancreatic Diversion 10/2014